THE ULTIMATE GUIDE TO AHU'S

Approximately eighty% of TTP is triggered by deficient action of ADAMTS13. ADAMTS13 deficiency can be constitutive, due to biallelic ADAMTS13 pathogenic variants; or obtained, due to an inhibitory antibody. Evaluation of ADAMTS13 action is executed employing checks according to the capability in the protease to cleave typical VWF multimers in vitro